Etoshine MR

Etoshine MR Tablet is a medicine that is used for the treatment of Joint pain, Muscles pain, Joint swelling, Muscles stiffness in nerve diseases, Muscles stiffness in spinal, Muscles swelling and other conditions.

Etoshine MR Tablet contains Etoricoxib, and Thiocolchicoside as active ingredients.

Etoshine MR Tablet works by preventing the release of prostaglandins; reduces the swelling and pain.

ETORICOXIB is one of a group of medicines called selective COX-2 inhibitors. These belong to a family of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). •ETORICOXIB helps to reduce the pain and swelling (inflammation) in the joints and muscles of people with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout. Osteoarthritis is a disease of the joints. It results from the gradual breakdown of cartilage that cushions the ends of the bones. This causes swelling (inflammation), pain, tenderness, stiffness and disability.Rheumatoid arthritis is a long term inflammatory disease of the joints. It causes pain, stiffness, swelling, and increasing loss of movement in the joints it affects. It may also cause inflammation in other areas of the body.Gout is a disease of sudden, recurring attacks of very painful inflammation and redness in the joints. It is caused by deposits of mineral crystals in the joint. Anky losing spondylitis is an inflammatory disease of the spine and large joints.

Etoricoxib is a COX-2 selective inhibitor (approx. 106.0 times more selective for COX-2 inhibition over COX-1) from Merck & Co. Doses are 60, 90 mg/day for chronic pain and 120 mg/day for acute pain. Currently it is approved in more than 60 countries worldwide but not in the US, where the Food and Drug Administration (FDA) requires additional safety and efficacy data for etoricoxib before it will issue approval. Current therapeutic indications are: treatment of rheumatoid arthritis, psoriatic arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Note that approved indications differ by country.

How it works

Etoricoxib belongs to a group of medication called non-steroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the release of prostaglandins, which are pain causing chemicals specifically at the site of inflammation in the body.

Thiocolchicoside belongs to group of medicines called muscle relaxant. It is semi-synthetic derivative of naturally occurring compound colchicoside. It acts against chemical called gamma amino-butyric acid (GABA). It reduces the swelling (anti-inflammatory) and pain (analgesic), and relaxes the muscles.

It may also be used to provide relief in gout, Osteoarthritis (OA), Rheumatoid Arthritis (RA) and other similar conditions.

Use

Etoricoxib is used in the treatment of osteoarthritis, gout, rheumatoid arthritis, post operative pain and muscular pain.

Thiocolchicoside is used for muscle relaxation.

Adult: PO Osteoarthritis 60 mg once daily. Rheumatoid arthritis 90 mg once daily. Acute gout 120 mg once daily. Max duration: 8 days.

Etoshine MR Tablet is a medicine that is used for the treatment of Joint pain, Muscles pain, Joint swelling, Muscles stiffness in nerve diseases, Muscles stiffness in spinal, Muscles swelling and other conditions.

The complete list of uses for Etoshine MR Tablet is as follows:

  • Joint pain
  • Muscles pain
  • Joint swelling
  • Muscles stiffness in nerve diseases
  • Muscles stiffness in spinal
  • Muscles swelling
  • Mild to moderate pain during dental operations
  • Muscles stiffness in muscle diseases
  • Muscles stiffness in the joint diseases

 

Thiocolchicoside Is A Muscle Relaxant With Anti-Inflammatory And Analgesic Effects. It Is Used In Relieving Muscular Pain . This Combination Is Also Used For Rheumatologic, Orthopedic, And Traumatologic Pain .

—–Side effects——

Palpitations, Abdominal pain, Bruise, Change in blood test results, Dizziness, Fatigue, Headache, Increased blood pressure, Indigestion, Limb swelling, Constipation, Diarrhoea, Heartburn, Nausea.

Abdominal cramp, Abdominal bloating, Abdominal pain, Diarrhoea, Dizziness, Fatigue, Headache, Influenza like symptoms, Nausea, Weakness.

GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.

Alert your doctor if any of the following symptoms are severe or refuse to go away: – swelling of hands and legs. – rashes. – diarrhoea. – stomach pain. – tiredness.

The most commonly reported side-effects of Etoshine MR Tablet are Weight gain, Allergy, Changes in blood parameters related to liver, Irregular or fast heartbeat, Blurring of vision, and Nausea.

The following is a list of possible side effects that may occur from the use of Etoshine MR Tablet. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.

  • Weight gain
  • Allergy
  • Changes in blood parameters related to liver
  • Irregular or fast heartbeat
  • Blurring of vision
  • Nausea
  • Hallucinations
  • Change in appetite
  • Flu-like symptoms
  • Breathlessness
  • Heartburn
  • Abnormal blood counts
  • Vomiting
  • Swelling in the legs due to fluid retention
  • Sensation of spinning
  • Severe allergic rejection
  • Depression
  • Ringing in ears
  • Heart problems
  • Kidney problems
  • Constipation
  • Diarrhea
  • Swelling of face
  • Stomach inflammation
  • Nosebleeds
  • Stomach pain
  • Dizziness
  • Indigestion
  • Stomach discomfort
  • Anxiety
  • Sleep disturbances
  • Gas
  • Mouth ulcers
  • Rise in blood pressure
  • Weakness
  • Fatigue
  • Headache
  • Urge to vomit
  • Brief loss of consciousness
  • Sleepiness Weakness
  • Symptoms due to exposure to sunlight

——-Etoshine MR Tablet Precautions——

Do not take Etoricoxib if you have a history of allergic reactions (swollen eyes or mouth, difficulty breathing, rashes) to similar medicines such as aspirin, celecoxib, diclofenac, mefenamic acid, ibuprofen, indomethacin. Always ask your doctor or pharmacist if you are not sure. Etoricoxib may not be suitable for you if you have a history of heart, kidney, liver or blood clotting problems, stroke, high blood pressure, bowel inflammation or stomach ulcers. Alert your doctor if you have any of these conditions.

Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

  • Above 65 years of age
  • Avoid smoking
  • Consult a doctor if you have allergic reactions
  • Consult a doctor if you have an allergic disorders, coagulation defects, left ventricular dysfunction or hypertension
  • Limit alcoholic beverages
  • Monitor blood pressure regularly
  • Pregnant or breastfeeding
  • Take doctor’s advice if you have oedema, renal, cardiac or hepatic impairment or gastrointestinal lesions
  • Take your doctor’s advice if you have diabetes or high cholesterol

——Etoshine MR Tablet Working, Mechanism of Action and Pharmacology——-

Etoshine MR Tablet improves the patient’s condition by performing the following functions:

  • Preventing the release of prostaglandins.
  • Reduces the swelling and pain.

 

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