What is avanafil?

Avanafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.

  • Avanafil is used to treat erectile dysfunction (impotence).
  • Avanafil may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking avanafil?

You should not take avanafil if you are allergic to it.

Taking avanafil with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take avanafil if you also take riociguat (Adempas), or if you take a nitrate drug for chest pain or heart problems. Nitrates include nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite (“poppers”).

To make sure avanafil is safe for you, tell your doctor if you have:

  • heart disease or heart rhythm disorder;
  • a recent history (in the past 6 months) of heart surgery;
  • a history of heart attack, stroke, or life-threatening heart rhythm problem;
  • congestive heart failure;
  • angina (chest pain), high or low blood pressure;
  • liver disease, kidney disease (or if you are on dialysis);
  • a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;
  • a bleeding disorder such as hemophilia;
  • a stomach ulcer;
  • hearing or vision problems, history of vision loss;
  • retinitis pigmentosa (an inherited condition of the eye);
  • a physical deformity of the penis (such as Peyronie’s disease); or
  • if you have been told you should not have sexual intercourse for health reasons.

Avanafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking Viagra or other drugs similar to avanafil. Most of these people also had certain pre-existing eye problems or risk factors for blood vessel disorders (such as heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether avanafil is the actual cause of vision loss.

Avanafil is not for use in women. It is not known whether avanafil will harm an unborn baby.

Although avanafil is not for use in women, it is not known if this medicine passes into breast milk or if it could harm a nursing baby.

How should I take avanafil?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Avanafil can be taken with or without food.

Avanafil is usually taken only when needed, about 30 minutes before sexual activity. Follow your doctor’s instructions.

Avanafil can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.

Do not take avanafil more than once a day. Allow 24 hours to pass between doses.

 

Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Since avanafil is used as needed, you are not likely to be on a dosing schedule.

What should I avoid while taking avanafil?

Drinking alcohol can increase certain side effects of avanafil. Avoid drinking more than 3 alcoholic beverages while you are taking avanafil.

Grapefruit and grapefruit juice may interact with avanafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking avanafil.

This medication will not protect you from sexually transmitted diseases–including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.

Avanafil side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using avanafil and get emergency medical help if you have sudden vision loss.

During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of avanafil.

Stop using avanafil and call your doctor at once if you have:

  • vision changes, sudden vision loss;
  • ringing in your ears, or sudden hearing loss;
  • heart attack symptoms–chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • pain, swelling, warmth, or redness in one or both legs;
  • shortness of breath, swelling in your hands or feet;
  • a light-headed feeling, like you might pass out; or
  • penis erection that is painful or lasts 4 hours or longer.
  • Common side effects may include:
  • headache;
  • flushing (warmth, redness, or tingly feeling);
  • cold symptoms such as runny or stuffy nose, sore throat; or
  • back pain.

Before taking avanafil

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking avanafil it is important that your doctor knows:

  • If you have any disease, injury or deformity of your penis.
  • If you have an irregular heartbeat, a heart condition, or blood vessel disease.
  • If you have had an eye condition causing loss of vision.
  • If you have high or low blood pressure, or angina.
  • If you have any problems with the way your liver works or with the way your kidneys work.
  • If you have had a stroke or a heart attack.
  • If you have a condition which causes bleeding, such as a stomach ulcer.
  • If you have sickle cell disease.
  • If you have ever had bone marrow cancer or leukaemia.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines, and recreational drugs.
  • If you have ever had an allergic reaction to a medicine.

How to take avanafil tablets

Before you take avanafil, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about the tablets and will provide you with a full list of the side-effects which you may experience from taking them.

Take avanafil exactly as your doctor tells you to. It is intended to be taken before sexual activity – it is NOT for continuous daily use. You should take one tablet about 15-30 minutes before you plan to have sex. You can take the tablet either before or after food but, if you have just eaten a meal, it may take longer for it to work.

There are three strengths of avanafil tablets: 50 mg, 100 mg and 200 mg. It is likely that you will be given the 100 mg strength tablet to begin with, but this may be changed subsequently depending upon how you react. Each time you collect a prescription, check to make sure it contains the strength of tablet you are expecting.

Do not take more than one dose of avanafil in any 24-hour period.

Getting the most from your treatment

You and your partner will still need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction. Avanafil will not cause an erection unless you are sexually aroused.

Do not drink large amounts of alcohol before you plan to take avanafil. Drinking too much alcohol can reduce your ability to get an erection and this may prevent you from getting the maximum benefit from the tablets. The combination of avanafil and alcohol will also increase your risk of side-effects such as dizziness.

It is recommended that you do not drink grapefruit juice during the 24 hours before you take avanafil. This is because there is a chemical in grapefruit juice which can increase the amount of avanafil in your bloodstream and this makes side-effects more likely.

Keep your regular appointments with your doctor so your progress can be monitored. If you feel the tablets are too strong for you, discuss this with your doctor as your dose may need to be reduced. Alternatively, if you do not get an erection after taking avanafil, or if it does not last long enough for you to have sex, you should discuss this with your doctor – do not take more tablets than you have been told to.

You should not take avanafil if you are using any other products or taking any other medicines to treat erectile dysfunction.

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