What is Cofdex?

Cofdex Capsule is a medicine that is used for the treatment of Cough, Common cold, Runny nose, Sneezing I Itching, Watery eyes caused by allergies, Flu and other conditions also Cofdex Capsule contains Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and Phenylpropanolamine as active ingredients.

Cofdex Capsule works by blocking a natural chemical that makes during an allergic rejection; stimulating alpha-adrenergic receptors which produce vasoconstriction and reduces tissue edema and nasal congestion affecting the signals in the brain that trigger cough reflex;

Detailed information related to Cofdex Capsule’s uses, composition, dosage, side effects and reviews is listed below.


Cofdex Capsule Uses


  • Cough
  • Common cold
  • Runny nose
  • Sneezing I Itching
  • Watery eyes caused by allergies
  • Flu
  • Allergies due to food
  • Appetite suppressor
  • Congestion
  • Sinusitis



Cofdex Capsule Working, Mechanism of Action and Pharmacology

Cofdex Capsule improves the patient’s condition by performing the following functions:

Blocking a natural chemical that makes during an allergic rejection.

Stimulating alpha-adrenergic receptors which produce vasoconstriction and reduces tissue edema and nasal congestion.

Affecting the signals in the brain that trigger cough reflex.


Cofdex Capsule Composition and Active Ingredients

Cofdex Capsule is composed of the following active ingredients (salts)

  • Chlorpheniramine Maleate (2 Mg)
  • Phenylpropanolamine (12.5 Mg)
  • Dextromethorphan Hydrobromide (10 Mg)


Cofdex Capsule – Side-effects

The following is a list of possible side effects that may occur from all constituting ingredients of Cofdex Capsule. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.

  • CNS Depression
  • Sedation
  • Drowsiness
  • Lassitude
  • Gastrointestinal upsets
  • Anorexia

Cofdex Capsule Precautions & How to Use

Before using this drug, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

  • Avoid alcohol consumption
  • Avoid its continuous use for longer than 3 months
  • Children under the age of 4 years
  • Consult your doctor in case of bladder neck obstruction and hypertension
  • Do not drive or operate heavy machinery

Composit uses/ indication of Cofdex :

Hay fever (allergic rhinitis), urticaria (hives), and other skin allergies. sneezing, runny nose, itchy or burning eyes. Mild to moderate pain from headaches.

Cough suppressants that work by providing relief from persistent dry irritant coughs.

Pain reliever and a fever reducer

Apnoea of prematurity, CNS stimulation, Headache, Migraine, Asthma, Lumbar puncture headache.

Bronchospasm, Nasal congestion, Rhinitis, Upper respiratory tract infections.

Composit contra indication of Cofdex :

Hypersensitivity.Pregnancy and lactation. Children below the age of two years.

Hypersensitivity. Severe hepatic impairment

Cardiac arrhythmia, Peptic ulcer. Do not administer solutions containing sodium benzoate to children.

Composit side effects of Cofdex :

Dizziness, Headache, Drowsiness, Fatigue, Nausea, Vomiting, Diarrhea, Constipation, Dry mouth, Pruritus, Sedation, Epigastric pain, gastric reflux. Sinus tachycardia, Hair loss, Tinnitus, Hypotension, Insomnia, Blood dyscrasias, Tremors.

Gastrointestinal upset, Vertigo, Sudden infant death syndrome, body rash/itching, nausea, drowsiness, dizziness, Closed-eye hallucination, Difficulty breathing

Epigastric distress, nausea, rashes, leucopenia is rare, Acute renal tubular necrosis. Very rare, blood dyscrasias.

Tachycardia, Caffeinism, Irregular fever, CNS stimulation, Diuresis. Emesis, Metabolic acidosis, Ketosis, Hyperglycemia, Acetonuria. Irritability, Nausea, Vomiting, Anorexia, Anxiety, Restlessness, Tremors, Insomnia, Epigastric pain.

Hypertension, Unconsciousness, Tachycardia, Hallucinations, Restlessness, Excitation, Hyperreflexia, Rapid Speech, Hypertonicity, Pupillary dilatation. Drowsiness, Anorexia, Anxiety, Restlessness, Insomnia, Sleep disturbancesX, Dry mouth, Tremor.

Composit caution of Cofdex :

Severe hepatic damage, epilepsy, renal insufficiency.

Patients suffering from chronic cough, asthma or where cough is accompanied by excessive secretions should be advised to consult a doctor before use. Stop use and ask doctor if cough lasts more than 7 days, comes back or is accompanied by a fever, rash or persistent headache.

Renal or hepatic impairment; alcohol-dependent patients; G6PD deficiency.

Caffeine should be used with caution in diabetic patients because it may produced hyperglycemia, in anxiety disorder or panic disorder because it can aggrevate these conditions, in hepatic disease or hepatic impairment and during pregnancy and breast feeding.

Hyperthyroidism, ischaemic heart disease, arrhythmia or tachycardia, occlusive vascular disorders e.g. arteriosclerosis, hypertension or aneurysms, DM and closed-angle glaucoma, renal impairment, prostatic enlargement. Pregnancy, lactation.

  • This is a bottle of 1000 Cofdex tablets. It contains 30 mg of

dextromethorphan (DXM) per tablet and is mainly used as a cough

suppressant. However, DXM has a cult following due to its remarkable

NMDA antagonist effects. It’s used recreationally by people who like

psychedelics or just a good old mind fuck. I would describe the

experience as a cross between ketamine (another NMDA antagonist) and

acid (LSD). I usually take 20 tablets but you need to calculate your

body weight to know what dose will push you to the trippy third plateau.


The interesting aspect of DXM is that it brings you to different

plateaus, with each one giving you a different experience, depending on

the dosage (which is calculated by body weight). I’m about 56 kg so 600

mg would put me to the third plateau, which is the one I always aim

for. I didn’t like DXM the first time I tried it, I thought it didn’t

give me much effects. The same goes for the second time. However, it

put me into a very heavy trip the third time, where you can see my thought process on DXM [sixthseal.com]. That post was written under the influence of DXM. It’s a real mind fuck.


It’s hard to obtain Robitussin DX here and pure DXM tablets are hard

to find too. You do not want antihistamines or pseudoephedrine in your

dose if you’re aiming for a high plateau. I was surprised to find that

my pharmacy friend has a bottle of it and I got it off him for RM 150.

We didn’t count the tablets; I just offered him that price by looking

at the remainders. It turned out to be more than 300 tablets. I take

DXM occasionally when I want to learn something or just trip.


  • The trick to getting effects from DXM is to fast (don’t eat

anything) for at least 18 hours beforehand and then dump the whole load

at once. Otherwise, it’ll just give you a slight puzzling drunken

feeling, and not a full out trip. This one need an empty stomach for it

to “work” and you need to “hold it down” i.e. not throw up. ) I only

learned that during the third time I tried it.


DXM is not commonly available in Malaysia – the cough suppressant of

choice is codeine, but if you see DXM HBr (without other active

ingredients) and you like ketamine, it feels something like that – with

less euphoria and more mind fuck..


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