What is Entacapone

This medication is catechol-o-methyltransferase (COMT) inhibitor, used as an adjunct to levodopacarbidopa to treat patients with idiopathic Parkinson?s disease. It is used during the later stages when the patient does not respond well to levodopacarbidopa. It increases the levels of levodopacarbidopa in the brain, enhancing its effectiveness.

How does Entacapone work:

Entacapone raises levodopa in the brain

How should Entacapone be used:

PO: The recommended dose is 200 mg with each levodopacarbidopa up to a maximum of 1600 mgday. It comes as a tablet to take by mouth.

Common side effects of Entacapone :

Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Extra muscle action or slow movement. Levodopacarbidopa dose may need to be changed. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Change in color of urine to brown or orange.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Entacapone :

If you have an allergy to entacapone or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are taking monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) talk with your doctor. Taking both at the same time could cause risky high blood pressure.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad dizziness. Change in thinking clearly and with logic. Very upset stomach or throwing up. Very loose stools (diarrhea). Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Entacapone with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. – Taking them together can cause bad side effects. – Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Entacapone :

Store it at room temperature and in airtight container. Keep away from children.

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Therapeutic Classification

Anticoagulants and Antiplatelets



Levodopa is used in the treatment of parkinson’s disease (a disorder of the nervous system that causes difficulties with movement and balance)

How it works

Levodopa works by being converted to dopamine, a chemical messenger that is needed to control movement in the brain.

Common side effects

Confusion, Insomnia, Vomiting, Anxiety, Headache, Dizziness, Orthostatic hypotension (sudden lowering of blood pressure on standing), Dry mouth, Nausea, Constipation, Uncoordinated body movements, Abnormal dreams



Carbidopa is used in the treatment of parkinson’s disease (a disorder of the nervous system that causes difficulties with movement and balance)

How it works

Carbidopa is always given with levodopa. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.

Common side effects

Nausea, Neuroleptic malignant syndrome, Panic attacks, Altered behaviour, Mood changes, Altered sleep, Burning sensation of tongue, Confusion, Convulsion, Dizziness, Drowsiness, Fever, Frequent dreams, Hallucination, Increased sweating, Tachycardia, Irregular heart rate, Tremor, Vomiting, Worsening of tremor, Muscle stiffness



Entacapone is used in the treatment of parkinson’s disease (a disorder of the nervous system that causes difficulties with movement and balance)

How it works

Entacapone works by increasing the amount of dopamine, a chemical messenger that is needed to control movement in the brain.

Common side effects

Nausea, Vomiting, Fatigue, Confusion, Angina pectoris, Constipation, Insomnia, Nightmare, Hallucination, Increased sweating, Fall, Abnormality of voluntary movements, Urine discolouration

Syncapone-150mg Tab Salt Information :

Uses of Syncapone-150mg Tab:

Carbidopa And Levodopa Combination Is Used To Treat The Symptoms Of Parkinson’s Disease. Carbidopa And Levodopa Is Also Prescribed In Other Conditions Where Parkinson Like Symptoms May Be Present Like As In Case Of Encephalitis Or Injury To The Nervous System Caused By Carbon Monoxide Poisoning Or Manganese Poisoning.

Side Effects of Syncapone-150mg Tab:

Nausea, Vomiting, Anorexia, Increased Risk Of GI Bleeding In Peptic Ulcer Patients. Orthostatic Hypotension, Cardiac Arrhythmias. Psychiatric Symptoms (Depression With Or Without Suicidal Tendency). Abnormal Involuntary Movements Or Dyskinesias, Delirium, Hallucinations (Elderly). Slight Elevation Of Liver Enzymes, Leucopenia And Thrombocytopenia. Potentially Fatal: Severe Postural Hypotension In Elderly.

Drug Interactions of Syncapone-150mg Tab:

Pyridoxine Reverses Effects Of Levodopa. Type-B MAOIs Have Synergistic Effect. Effect Reduced By Phenothiazines, Haloperidol, Reserpine, Pyridoxine, Diazepam, Oxazepam, Chlordiazepoxide, Phenobarbitone. Effects Of Levodopa Enhanced By Carbidopa, Amantadine, Anticholinergics, Amphetamine. Effects Of Sympathomimetic Agents Enhanced. Potentially Fatal: Enhances Hypotensive Effects Of Bethanidine, Bretylium, Guanethidine. Hypertensive Crises With Furazolidone Or MAO Inhibitors.

Contraindications of Syncapone-150mg Tab:

Lactation, Narrow Angle Glaucoma, Melanoma, Psychosis, Severely Decompensated Endocrine.

Mechanism of Action of Syncapone-150mg Tab:

Levodopa, A Precursor Of Dopamine, Crosses The Blood-Brain Barrier And Gets Converted To Dopamine In The Basal Ganglia While Carbidopa Is A Dopa-Decarboxylase Inhibitor. The Latter Prevents Conversion Of L-Dopa To Dopamine Outside The Brain And Minimizes Side Effects.

Special Precautions for Syncapone-150mg Tab:

Heart Disease, Liver Disease, Dementia, Psychosis, Pregnancy, Elderly, Heart Disease. Regular Monitoring Of Renal And Hepatic Function Is Recommended.

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