What is Lescol?

Lescol (fluvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or “statins.” Fluvastatin reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of “good” cholesterol (high-density lipoprotein, or HDL).

Lescol is used to lower cholesterol and triglycerides (types of fat) in the blood and to slow the build-up of plaque (fatty deposits) in your blood vessels.

Lescol is also used to lower the risk of heart complications in certain people with coronary artery disease. Fluvastatin is used in adults and children who are at least 10 years old.

Important information

Lescol can harm an unborn baby or cause birth defects. Do not use fluvastatin if you are pregnant.

You should not take Lescol if you have liver disease, or if you are breast-feeding a baby.

Before taking Lescol, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, or if you drink more than 2 alcoholic beverages daily.

Some medicines can cause unwanted or dangerous effects when used with fluvastatin. Tell your doctor about all other medicines you use.

In rare cases, fluvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

 

Avoid eating foods that are high in fat or cholesterol. Lescol will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Lescol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Before taking this medicine

You should not take Lescol if you are allergic to fluvastatin, or if:

  • you have active liver disease; or
  • you are pregnant or breast-feeding.

To make sure Lescol is safe for you, tell your doctor if you have:

  • a history of liver disease;
  • muscle pain or weakness;
  • kidney disease;
  • diabetes;
  • a thyroid disorder; or
  • if you drink more than 2 alcoholic beverages daily.

Lescol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

The following drugs can increase your risk of serious muscle problems if you take them together with Lescol:

  • colchicine;
  • erythromycin;
  • fluconazole;
  • glyburide;
  • phenytoin;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cyclosporine or other drugs that weaken your immune system;
  • gemfibrozil, fenofibric acid, fenofibrate; or

medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others).

Lescol can harm an unborn baby or cause birth defects. Do not take Lescol if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Use effective birth control to prevent pregnancy while you are taking this medicine.

Fluvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Lescol.

This medicine is not approved for use by anyone younger than 10 years old.

How should I take Lescol?

Take Lescol exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

Lescol is usually taken once or twice daily, with or without food. Take the medicine at the same time each day.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Tell your doctor if you have trouble swallowing the pill.

Lescol side effects

  • Chills
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • muscle aches and pain
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • Bladder pain
  • bloody or cloudy urine
  • cough producing mucus
  • dark-colored urine
  • difficult, burning, or painful urination
  • difficulty with breathing
  • difficulty with moving
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • frequent urge to urinate

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