What is Sovaldi?

Sovaldi (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) from multiplying in your body.

Sovaldi is used in combination with other medications to treat hepatitis C in adults. Sofosbuvir is sometimes used in people who also have HIV, or people who have liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.

Sovaldi must be given in combination with other antiviral medications and should not be used alone. Sovaldi is usually given with ribavirin (Copegus, Rebetol, Ribasphere, RibaTab) with or without peginterferon alfa (Pegasys, PegIntron).

Sovaldi is also used together with Daklinza (daclatasvir) to treat hepatitis C genotype 3 infection in adults.

Important information

Sovaldi is used in combination with other medications, usually ribavirin with or without peginterferon alfa.

Read the medication guide or patient instructions provided with each medication in your combination therapy. Do not change your doses or medication schedule without your doctor’s advice.

Ribavirin can cause birth defects or death in an unborn baby. Do not use sofosbuvir with ribavirin if you are pregnant, or if you are a man and your female sexual partner is pregnant. Use at least 2 effective forms of non- hormonal birth control while using these medicines together and for at least 6 months after treatment ends.

If you have ever had hepatitis B, Sovaldi can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function.

Before taking this medicine

You should not use Sovaldi you are allergic to sofosbuvir.

To make sure Sovaldi is safe for you, tell your doctor if you have:

  • a history of hepatitis B;
  • liver problems other than hepatitis, or if you have had a liver transplant;
  • kidney disease (or if you are on dialysis);
  • HIV (human immunodeficiency virus); or
  • if you have recently used a heart rhythm medicine called amiodarone (Cordarone, Pacerone).

Sovaldi is used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before using these medications together, and every month during your treatment.

If you are a woman, do not use Sovaldi with ribavirin if you are pregnant.

If you are a man, do not use this drug combination if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.

Use at least 2 effective forms of non hormonal birth control (condom, diaphragm with spermicide) while either sexual partner is using these medications together. Keep using 2 forms of birth control for at least 6 months after treatment ends. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Sovaldi with ribavirin.

It is not known whether sofosbuvir passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Sovaldi?

Do not take Sovaldi as your only medication to treat hepatitis C. It must be used in combination with other antiviral medication. Your disease may become resistant if you do not take it in combination with other medicines your doctor has prescribed.

Sovaldi is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take this medicine with or without food. Take the medicine at the same time each day.

Store this medicine in the original container at room temperature away from moisture and heat.

Sovaldi dosing information

Usual Adult Dose for Chronic Hepatitis C:

400 mg orally once a day

What should I avoid while taking Sovaldi?

Taking this medication will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Sovaldi side effects

  • Chills
  • fever
  • lower back or side pain
  • pale skin
  • ulcers, sores, or white spots in the mouth
  • unusual tiredness or weakness
  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • loss of interest or pleasure
  • thoughts of killing oneself
  • trouble concentrating
  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness

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