Antiparkinson agents aim to replace dopamine either by drugs that release dopamine or those that mimic the action of dopamine. Parkinson’s disease is a degenerative disorder of movement that occurs due to dopamine deficiency in the basal ganglia. Antiparkinson agents attempt to replace dopamine and treat or halt the symptoms such as tremor, hypokinesia, and so on.
Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. In PD, cells in a part of the brain called the substantia nigra die off. The normal function of these cells is to regulate the action of other cells in other brain regions by releasing a chemical called dopamine. When substantia nigra cells release dopamine, the dopamine attaches to dopamine receptors on the other cells, which influences them in various ways depending on the specific type of cell. The actions of these cells work in concert with other systems that influence movement. When all cells are working properly together, the end result is controlled, fluid movement.