How does this medication work?
Allopurinol is an inhibitor of xanthine oxidase, a substance in the body that is responsible for the product of uric acid. It is used to prevent gout, kidney stones, and kidney damage caused by uric acid. It is also used to reduce the levels of uric acid in the blood that occur because of blood disorders associated with cancer such as leukemias and lymphomas.
What form(s) does this medication come in?
Each white, round, biconvex, scored tablet engraved with “ALL” over “100” on one side contains allopurinol 100 mg. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, and colloidal silicon dioxide.
Each peach, round, biconvex, scored tablet engraved with “ALL” over “200” on one side contains allopurinol 200 mg. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and Sunset Yellow Aluminium Lake.
Each orange, round, biconvex, scored tablet engraved with “ALL” over “300” on one side contains allopurinol 300 mg. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and Sunset Yellow Aluminium Lake.
How should I use this medication?
The recommended dose ranges from 100 mg to 800 mg daily in 1 to 3 divided doses taken after food, depending on the condition being treated.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Who should NOT take this medication?
Allopurinol should not be given to or taken by anyone who:
- is allergic to, or who has previously developed a severe reaction to, allopurinol or any ingredients of this medication
- is a child (except for high levels of uric acid caused by cancer)
- is a nursing mother (except for high levels of uric acid caused by cancer)
What side effects are possible with this medication?
- nausea or vomiting occurring without other side effects
- stomach pain occurring without other side effects
- taste perversion
- unusual hair loss
- Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- loosening of fingernails
- numbness, tingling, pain, or weakness in hands or feet
- pain in lower back or side
- unexplained nosebleeds
- black, tarry stools
- bleeding sores on lips
- blood in urine or stools
- chills, fever, muscle aches or pains, nausea or vomiting (especially if this happens with or shortly after a skin rash)
- difficult or painful urination
- pinpoint-sized red spots on skin
- red, thickened, or scaly skin
- red or irritated eyes
- redness, tenderness, burning, or peeling of skin
- shortness of breath, trouble breathing, tightness in chest, or wheezing
- skin rash or sores
- sore throat and fever
- sores, ulcers, or white spots in mouth or on lips
- sudden decrease in amount of urine
- swelling in stomach area
- swelling of face, fingers, feet, or lower legs
- swollen or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- weight gain (rapid)
- yellow eyes or skin
Are there any other precautions or warnings for this medication?
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Drowsiness/reduced alertness: This medication may make you drowsy. Use appropriate caution if you plan to do activities requiring alertness.
What other drugs could interact with this medication?
There may be an interaction between allopurinol and any of the following:
- aluminum salts (e.g., antacids containing aluminum)
- salicylates (e.g., ASA)
- theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
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