Dinex EC 400 (Didanosine 400mg)
What is Dinex EC (didanosine)?
Didanosine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Didanosine is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Didanosine is not a cure for HIV or AIDS. Didanosine is for use in adults and children who are at least 2 weeks old. Didanosine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Dinex EC (didanosine)?
Do not take didanosine together with allopurinol or ribavirin.
Didanosine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.
This medicine can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have: severe pain in your upper stomach (may spread to your back), nausea and vomiting, fast heart rate, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
What should I discuss with my healthcare provider before taking Dinex EC (didanosine)?
You should not use didanosine if you are allergic to it.Do not take didanosine together with allopurinol (Zyloprim, Lopurin, Aloprim) or ribavirin (Rebetol, Ribasphere, Copegus, Virazole). Some people taking didanosine develop a serious condition called lactic acidosis. This may be more likely in women, in people who are overweight or have liver disease, and in people who have taken HIV/AIDS medication for a long time. Talk with your doctor about your risk.
To make sure didanosine is safe for you, tell your doctor if you have: liver disease or a history of pancreatitis (didanosine can cause severe or life-threatening effects on your liver or pancreas); kidney disease; a history of numbness or tingling in your hands or feet, including Raynaud’s syndrome; if you drink large amounts of alcohol; or if you also take stavudine (Zerit).
If you are pregnant, do not take didanosine together with stavudine. This combination of medicines can cause lactic acidosis or liver problems, which can be very dangerous during pregnancy.
HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of didanosine on the baby. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
How should I take Dinex EC (didanosine)?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take didanosine on an empty stomach, at least 30 minutes before or 2 hours after a meal. Do not take with food. Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Do not crush, chew, break, or open a delayed-release capsule. Swallow it whole. HIV/AIDS is usually treated with a combination of drugs, but certain HIV medications or antibiotics should not be taken at the same time as didanosine.
These other medicines can affect the levels of didanosine in your blood stream:
- Ciprofloxacin (Cipro) should be taken at least 2 hours before or 6 hours after you take didanosine.
- Delavirdine (Rescriptor) or indinavir (Crixivan) should be taken at least 1 hour before you take didanosine.
- Nelfinavir (Viracept) should be taken at least 1 hour after you take didanosine.
- Itraconazole (Sporanox) or ketoconazole (Nizoral) should be taken at least 2 hours before you take didanosine.