Lenmid 10mg (Lenmidomide)
Description of Lenmid
Lenmid 10mg capsule is an immunomodulating agent that affects the working of immune system to help the bone marrow in making new & normal blood cells & erasing the abnormal cells from the bone marrow. The Lenmid 10mg capsules are sometimes taken in combination with other medicines to treat anaemia in the myelodysplastic & multiple myeloma patients. Lenmidomide capsule is also used along with dexamethasone to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with at least one other medication.
Uses of Lenmid
Lenmidomide is used in adults in combination with other medicines to treat multiple myeloma (a type of cancer which affects plasma cells, a certain type of white blood cell) and alone to treat myelodysplastic syndromes (collection of many different blood and bone marrow diseases). It is also used to treat mantle cell lymphoma (aggressive variety of cancer that occurs in lymph nodes).
How Lenmid works
Lenmidomide is an immunomodulatory and an antiangiogenic agent. It works by stopping the growth of cancer cells in the body.
Mechanism of action.
Lenmidomide has been used to successfully treat both inflammatory disorders and cancers in the past 10 years. There are multiple mechanisms of action, and they can be simplified by organizing them as mechanisms of action in vitro and in vivo. In vitro, cheap Lenmidomide has three main activities: direct anti-tumor effect, inhibition of the microenvironment support for tumor cells, and immunomodulatory role. In vivo, Buy Lenmidomide induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.Lenmidomide has a broad range of activities that can be exploited to treat many hematologic and solid cancers.
The proposed mechanisms of action of Lenmidomide in multiple myeloma (MM) include direct cytotoxicity via induction of apoptosis (A); inhibition of cell adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), which reduces the growth signaling of MM cells (B); inhibition of growth signals that promote bone marrow angiogenesis, such as vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), and interleukin (IL)-6 (C); and stimulation of the T-helper cells, which increases production of IL-2 and interferon-γ (IFN-γ) and consequently augments natural killer (NK) cell activation and NK cell-dependent cytotoxicity (D). Illustration by Taina Litwak, CMI.
Treatment of multiple myeloma.
Multiple myeloma is a cancer of the blood, characterized by accumulation of a plasma cell clone in the bone marrow. Lenmidomide is one of the novel drug agents used to treat multiple myeloma. It is a small molecular analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenmidomide is 100,000 times more potent than thalidomide in inhibiting tumor necrosis factor-alpha, and has less severe adverse drug reactions. In a phase III clinical study, Weber et al. found that Lenmidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma was superior to the old treatment of multiple myeloma consisting of high-dose dexamethasone alone.
Dosage of Lenmid
Always follow the instructions of doctor regarding the dosage and duration.
- Multiple Myeloma and mantle cell lymphoma: 10 mg/day on days 1 through 21 of repeated 28 day cycles.
- Myelodysplastic Diseases: 10 mg once daily.
- This information is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
Common side effects
Anemia, low levels of calcium, phosphate, potassium or magnesium in the blood, iron overload, changes to blood thyroid hormone, vasculitis (changes to a protein in the blood that can cause swelling of the arteries), muscle cramps, muscle aches and weakness, bone/ joint pain, pains in hands or feet, tiredness, generalized swelling, numbness, tingling or burning sensation, fever and flu, constipation, stomach pain, diarrhea, nausea, vomiting, decreased appetite, bleeding from the gums, stomach, or bowels, kidney problems, dehydration, sore inflamed mouth, dry mouth, difficulty swallowing, heartburn, abnormal liver test results, chest pain or shortness of breath, high or low blood pressure, irregular heartbeat, heart problems, increased sweating, depression, dizziness, fainting, confusion, mood change, difficulty sleeping, tremor, impaired balance, movement difficulty, dry skin, darkening of skin, skin eruptions, skin cracking, flaking or peeling skin, hives, itching redness of skin, rashes, blurred vision, cataract, tinnitus (ringing in the ears), deafness, toothache, weight loss, diabetes.
Who should not take
- Patients who are allergic to Lenmidomide or any of its ingredients.
- Children or adolescents under 18 years of age.
- Pregnant or breastfeeding women.
Lenmid, Lenmidomide Capsules 10 mg
Lenmidomide is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic treatment. Lenmidomide has also shown efficacy in the class of hematological disorders known as myelodysplastic syndromes (MDS). Lenmidomide has significantly improved overall survival in myeloma (which generally carries a poor prognosis), although toxicity remains an issue for users.
What is Lenmid?
Lenmid is Generic version of Revlimid manufactured by Natco which is manufactured by Natco Pharma Ltd. (INDIA)
Lenmid is used for treatment of a certain type of myelodysplastic syndrome (a group of conditions in which the bone marrow produces blood cells that are misshapen and does not produce enough healthy blood cells) caused by an abnormal chromosome. Lenmid is also used for treatment of anemia (a lack of red blood cells in the body) and along with dexamethasone for the treatment of multiple myeloma (a type of cancer of the bone marrow) who have received at least one prior therapy.
What are the Indications of Lenmid?
Multiple Myeloma: Lenmidomide in combination with dexamethasone is indicated for the treatment of patients with multiple myeloma (MM) who have received at least one prior therapy.
Myelodysplastic Syndromes: Lenmidomide is indicated for the treatment of patients with transfusion-dependent anemia due to low-or intermediate-1-risk myelodysplastic syndromes (MDS) associated with a deletion 10q cytogenetic abnormality with or without additional cytogenetic abnormalities.
Mantle Cell Lymphoma: Lenmidomide is indicated for the treatment of patients with mantle cell lymphoma (MCL) whose disease has relapsed or progressed after two prior therapies, one of which included bortezomib.
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Interactions with Medicines
Using Lenmidomide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Proper Use of Lenmidomid
Take Lenmidomide exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking Lenmidomide without checking with your doctor first. Direct any questions to your doctor or pharmacist before starting Lenmidomide therapy. .
You should take the necessary precautions to avoid pregnancy while taking Lenmidomide. Use one highly effective form of birth control plus an additional effective form of birth control at the same time, if abstinence is not the chosen method. Begin this 4 weeks before starting Lenmidomide and continue it for 4 weeks after stopping the medication.
Ask your doctor or pharmacist if you have any questions about what you need to do.
Swallow the capsule whole, do not break, chew, or open it.
Before taking Lenmid (Lenmidomide) you must tell your physician if you are receiving dialysis, have a tumor, cancer, or kidney problems.
It is extremely important that women do not become pregnant while taking this drug as it can cause birth defects in unborn children. It can also be passed on through sexual intercourse with a man who is taking the medication. Make sure to always use precautions when having sexual intercourse with pregnant women when taking this drug.
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