Sulindac Information

Treating rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis. It is used to treat gout or certain types of bursitis and tendonitis. It may also be used for other conditions as determined by your doctor.

Sulindac is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use sulindac if:

  • you are allergic to any ingredient in sulindac
  • you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
  • you have recently had or will be having bypass heart surgery
  • you are also taking another NSAID (eg, ibuprofen)
  • you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using sulindac:

Some medical conditions may interact with sulindac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney or liver disease, diabetes, stomach or bowel problems (eg, bleeding, perforation, ulcers), or inflammation of the pancreas
  • if you have a history of swelling or fluid buildup, kidney stones, asthma, growths in the nose (nasal polyps), or mouth inflammation
  • if you have high blood pressure, a blood disorder, bleeding or clotting problems, heart problems (eg, heart failure), lupus or other connective tissue disease, or blood vessel disease, or if you are at risk for any of these diseases
  • if you have poor health, dehydration or low fluid volume, or low blood sodium levels, if you drink alcohol, or if you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with sulindac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Bisphosphonates (eg, alendronate, risedronate) because the risk of stomach or bowel problems may be increased. Contact your doctor if you experience heartburn, stomach pain, nausea or vomiting, or a sensation of fullness

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, other NSAIDs (eg, ibuprofen), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of sulindac’s side effects

Diflunisal or dimethyl sulfoxide (DMSO) because they may decrease sulindac’s effectiveness

Cyclosporine, lithium, methotrexate, quinolones (eg, ciprofloxacin), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by sulindac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin receptor blockers (eg, losartan), or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by sulindac

This may not be a complete list of all interactions that may occur. Ask your health care provider if sulindac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use sulindac:

Use sulindac as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sulindac comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get sulindac refilled.

Take sulindac by mouth with food. This may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor if you have persistent stomach upset.

Take sulindac with a full glass of water (8 oz/240 mL) as directed by your doctor.

Drinking extra fluids while you are taking sulindac is recommended. Check with your doctor for instructions.

If you miss a dose of sulindac and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use sulindac.

Important safety information:

Sulindac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use sulindac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of sulindac. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking sulindac with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Sulindac is an NSAID. Before you start taking any new medicine, read the ingredients. If it also has an NSAID (eg, ibuprofen) in it, check with your doctor. If you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using sulindac unless your doctor tells you to.

Diabetes patients – Sulindac may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use sulindac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use sulindac with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Sulindac should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Sulindac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using sulindac while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking sulindac.

Major Side Effects

More common:

  • Acid or sour stomach
  • belching
  • constipation
  • headache
  • heartburn
  • nausea or vomiting
  • skin rash
  • stomach pain

Less common:

  • Excess air or gas in the stomach or intestines
  • itching skin
  • passing gas
  • stomach cramps
  • swelling
  • weight loss

Sulindac Pregnancy Warnings

Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy may cause significant adverse effects, including premature closure of the fetal ductus arteriosus, oligohydramnios, fetal renal impairment, platelet dysfunction, pulmonary hypertension, and gastrointestinal or intracranial bleeding. There are no controlled data in human pregnancy. NSAIDs may impair female fertility; withdrawal of NSAID therapy should be considered in women with difficulties conceiving or who are undergoing investigation of infertility. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Not recommended during last trimester of pregnancy. Prior to 30 weeks gestation: Use only if potential benefit justifies the potential risk to the fetus. AU TGA pregnancy category: C US FDA pregnancy category: C Comments: -Avoid use during third trimester as it may cause premature closure of the ductus arteriosus. -Not recommended in women attempting to conceive as may impair female fertility.

Sulindac Breastfeeding Warnings

Use is not recommended. Excreted into human milk: Unknown Excreted into animal milk: Yes Comments: The effects in the nursing infant are unknown.

Due to its long half-life and lack of published clinical experience during breastfeeding, other agents may be preferred.


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