Tenofovir is used for:

Treating HIV infection in combination with other medicines. It is also used to treat chronic HBV infection. It may also be used for other conditions as determined by your doctor.

Tenofovir is an antiviral reverse transcriptase inhibitor. It works to treat HIV infection by blocking the growth of HIV. It works to treat HBV infection by blocking the ability of the virus to multiply and infect new liver cells. Tenofovir is not a cure for HIV or HBV.

Do NOT use tenofovir if:

  • you are allergic to any ingredient in tenofovir
  • you have severe liver problems (eg, an enlarged liver) or lactic acidosis
  • you take adefovir or other medicines that contain tenofovir
  • you take a medicine that may harm your kidneys (eg, an aminoglycoside antibiotic [eg, gentamicin], amphotericin B, cyclosporine, a nonsteroidal anti-inflammatory drug [NSAID] [eg, ibuprofen], tacrolimus, vancomycin). Ask your doctor if you are not sure if any of your medicines might harm your kidneys

Contact your doctor or health care provider right away if any of these apply to you.

Before using tenofovir:

Some medical conditions may interact with tenofovir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney problems (including kidney problems from taking another medicine called adefovir), or if you are on dialysis
  • if you are overweight
  • if you have a history of abnormal liver function tests or liver problems
  • if you have both HIV and HBV infections
  • if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition), or if you have a history of bone problems (eg, fracture)
  • if you are unable to swallow tablets

Some MEDICINES MAY INTERACT with tenofovir. Tell your health care provider if you are taking any other medicines, especially any of the following:

Didanosine because the risk of its side effects may be increased by tenofovir

This may not be a complete list of all interactions that may occur. Ask your health care provider if tenofovir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use tenofovir:

Use tenofovir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with tenofovir. Talk to your pharmacist if you have questions about this information.

Take tenofovir by mouth with or without food.

Continue to take tenofovir even if you feel well. Do not miss any doses.

Taking tenofovir at the same time each day will help you remember to take it.

Do not suddenly stop taking tenofovir without checking with your doctor. This may cause the virus to become less sensitive to this or other medicines. If you have hepatitis B, your condition could become worse if you suddenly stop taking tenofovir.

If you miss a dose of tenofovir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use tenofovir.

Important safety information:

Tenofovir may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use tenofovir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

If you have HBV infection, you will need close medical follow-up for several months after stopping treatment with tenofovir. Follow-up includes medical exams and blood tests to check for HBV infection that could be getting worse.

Possible side effects of tenofovir:

  • Chest pain
  • cough
  • fever or chills
  • tightness in the chest
  • troubled breathing
  • Abdominal or stomach discomfort
  • decreased appetite
  • diarrhea
  • fast, shallow breathing
  • general feeling of discomfort
  • muscle pain or cramping
  • unusual tiredness or weakness
  • Agitation
  • bone pain
  • changes in urination
  • confusion
  • convulsions or seizures
  • depression
  • fast heartbeat
  • increased blood pressure
  • increased thirst
  • muscle twitching
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • stupor
  • swelling of the face, fingers, or lower legs
  • vomiting
  • weight gain
  • yellow eyes or skin

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