Tonact 20mg Tablet
Uses of Tonact 20mg
Atorvastatin Is A Member Of The Drug Class Known As Statins, Which Are Used Primarily As A Lipid-Lowering Agent . Atorvastatin Uses Include Treatment Of Dyslipidemia And The Prevention Of Cardiovascular Disease . Atorvasatin Reduces Level Of Cholestrol , HDL And Triglycerides Which Are Responsible For Cardio-Vascular Disorders.
Drug Interactions of Tonact 20mg
May Increase Risk Of Myopathy And Rhabdomyolysis W/ CYP3A4 Potent Inhibitor (E.G. HIV Or HCV Protease Inhibitors, Itraconazole, Clarithromycin), Fenofibrate, Colchicines, Fixed Combination Of Lopinavir/Ritonavir. May Decrease Plasma Concentration W/ CYP3A4 Inducer (E.G. Rifampicin, Efavirenz). May Significantly Increase AUC And Peak Plasma Concentration Of Digoxin. Increased AUC For Norethindrone And Ethinyl Estradiol. Potentially Fatal: Increased Risk Of Myopathy Or Rhabdomyolysis W/ Ciclosporin, Gemfibrozil, Telaprevir, Tipranavir.
Contraindications of Tonact 20mg
Active Liver Disease Or Unexplained Persistent Elevations Of Serum Transaminases. Concomitant Use W/ Ciclosporin, Gemfibrozil, Telaprevir, Tipranavir. Pregnancy And Lactation.
Mechanism of Action of Tonact 20mg
Atorvastatin Competitively Inhibits HMG-CoA Reductase, The Enzyme That Catalyses The Conversion Of HMG-CoA To Mevalonate. This Results In The Induction Of The LDL Receptors And Stimulation Of LDL Catabolism, Leading To Lowered LDL-Cholesterol Levels. Absorption: Readily Absorbed From The GI Tract. Bioavailability: Approx 12%. Distribution: Volume Of Distribution: Approx 381 L. Plasma Protein Binding: 98%. Metabolism: Metabolised By CYP3A4 Isoenzyme To Active Ortho- And Parahydroxylated Derivates And An Inactive ?-Oxidation Product. Excretion: Via Faeces (As Metabolites); Urine (<2% As Unchanged Drug). Elimination Half-Life: Approx 14 Hr.
Special Precautions for Tonact 20mg
History Of Liver Disease; Patients Who Consume Substantial Quantities Of Alcohol; Patients W/ Risk Factors For Myopathy Or Rhabdomyolysis. Hypothyroidism Should Be Properly Managed Prior To Statin Therapy Initiation. Renal Impairment. Childn <10 Yr. Premenarcheal Females. Monitoring Parameters Monitor Creatine Kinase (CK) Periodically And LFT. Discontinue If There Is Significant Or Persistent Increase In CK Levels, Serum Aminotransferase Levels Or Evidence Of Myopathy.
What is Tonact (20mg)?
Tonact (20mg) is in a group of drugs called HMG CoA reductase inhibitors, or “statins.” Tonact (20mg) reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of “good” cholesterol (high-density lipoprotein, or HDL). Tonact (20mg) is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. Tonact (20mg) is used in adults and children who are at least 10 years old. Tonact (20mg) may also be used for purposes not listed in Tonact (20mg) guide.
What should I avoid while taking Tonact (20mg)?
Avoid eating foods that are high in fat or cholesterol. Tonact (20mg) will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Grapefruit and grapefruit juice may interact with Tonact (20mg) and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Tonact (20mg) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Tonact (20mg) and call your doctor at once if you have any of these serious side effects: unexplained muscle pain, tenderness, or weakness; confusion, memory problems; fever, unusual tiredness, and dark colored urine; swelling, weight gain, urinating less than usual or not at all; increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious side effects may include: mild muscle pain; diarrhea; or mild nausea.
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