CA Atra 10mg (All-trans Retinoic Acid)
CA ATRA ( All-trans retinoic acid) is the generic version of Vesanoid
ATRA is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. ATRA is classified as a “retinoid.”
Tretinoin is one of a group of drugs called retinoids that are similar to vitamin A. It is not a chemotherapy drug, but you may have it along with chemotherapy to treat a type of acute myeloid leukaemia called promyelocytic leukaemia. Tretinoin is also called all trans retinoic acid (ATRA) and its brand name is CA Atra.ATRA is used to treat acute promyelocytic leukemia (APL, APML).
How ATRA Is Given:
- •ATRA is given by mouth (in capsule form).
- •One size capsule – 10mg, do not crush chew or dissolve capsules. Protect from light.
- •Take ATRA with food.
- •It also is used as a lotion (topical) for patients with acne and certain rashes.
The amount of ATRA you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dosage and schedule.
What is CA Atra (tretinoin)?
Tretinoin is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. Tretinoin is used to treat acute promyelocytic leukemia (a type of blood cancer). Tretinoin may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about CA Atra (tretinoin)?
Do not use if you are pregnant. You may need to have a pregnancy test every month during treatment.
What should I discuss with my healthcare provider before taking CA Atra (tretinoin)?
You should not use this medicine if you are allergic to tretinoin or to other retinoids (such as Accutane, Retin-A, Renova). This medicine can cause birth defects, miscarriage, premature birth, or death of a baby. Do not use tretinoin if you are pregnant. Tell your doctor right away if you miss a period or become pregnant during treatment. You may need to have a negative pregnancy test before starting this treatment, and every month while taking tretinoin.
Tretinoin can make certain birth control pills less effective. Ask your doctor about the best method of birth control to prevent pregnancy while taking tretinoin. You must use effective birth control while you are taking tretinoin unless you have had a hysterectomy and no longer have a uterus. Use birth control even if you have been infertile (unable to have children) in the past, or if you have gone through menopause. To make sure tretinoin is safe for you, tell your doctor if you have: high cholesterol; liver disease; or a history of blood clot or stroke. It is not known whether tretinoin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I use CA Atra (tretinoin)?
Your doctor will perform a blood test to make sure you have the type of leukemia this medicine is used to treat. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take each dose with a full glass of water. You may need to continue taking tretinoin for up to 90 days. Follow your doctor’s instructions. Store tretinoin at room temperature away from moisture, heat, and light. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include headache, dizziness, weakness, flushing (warmth, redness, or tingly feeling) in your face, stomach pain, and dry or cracked lips.
What should I avoid while using CA Atra (tretinoin)?
Do not use vitamin A supplements or multivitamins that contain vitamin A while you are taking tretinoin. This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient’s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
CA Atra (tretinoin) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; mouth and throat ulcers, red or swollen gums, burning mouth pain, trouble swallowing; increased pressure inside the skull–severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; kidney problems–little or no urinating, weight gain, swelling in your feet or ankles; liver problems–upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); lung problems–pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down); signs of a blood clot–sudden numbness or weakness (especially on one side of the body), problems with speech or balance, chest pain, coughing up blood, pain or warmth in one or both legs; signs of infection–fever, chills, flu symptoms, easy bruising or bleeding, new or worsening cough, stabbing chest pain, wheezing, rapid and shallow breathing; or signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.
Common side effects may include: fever, weakness, tiredness; nausea, vomiting; bone pain; rash, itching, dry skin, increased sweating; hair loss or skin changes; dry mouth, nose, or throat; headache; or vision changes.
What other drugs will affect CA Atra (tretinoin)?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with tretinoin, especially: an antibiotic–doxycycline, demeclocycline, minocycline, tetracycline. This list is not complete. Other drugs may interact with tretinoin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
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