Lenalid 10 mg (Lenalidomide)
Uses of Lenalid
Lenalidomide is used in adults in combination with other medicines to treat multiple myeloma (a type of cancer which affects plasma cells, a certain type of white blood cell) and alone to treat myelodysplastic syndromes (collection of many different blood and bone marrow diseases). It is also used to treat mantle cell lymphoma (aggressive variety of cancer that occurs in lymph nodes).
How Lenalid works
Lenalidomide is an immunomodulatory and an antiangiogenic agent. It works by stopping the growth of cancer cells in the body.
Mode of action
Lenalidomide has been used to successfully treat both inflammatory disorders and cancers in the past 15 years. There are multiple mechanisms of action, and they can be simplified by organizing them as mechanisms of action in vitro and in vivo. In vitro, cheap lenalidomide has three main activities: direct anti-tumor effect, inhibition of the microenvironment support for tumor cells, and immunomodulatory role. In vivo, Buy lenalidomide induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.Lenalidomide has a broad range of activities that can be exploited to treat many hematologic and solid cancers.
The proposed mechanisms of action of lenalidomide in multiple myeloma (MM) include direct cytotoxicity via induction of apoptosis (A); inhibition of cell adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), which reduces the growth signaling of MM cells (B); inhibition of growth signals that promote bone marrow angiogenesis, such as vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), and interleukin (IL)-6 (C); and stimulation of the T-helper cells, which increases production of IL-2 and interferon-γ (IFN-γ) and consequently augments natural killer (NK) cell activation and NK cell-dependent cytotoxicity (D). Illustration by Taina Litwak, CMI.
Treatment of multiple myeloma.
Multiple myeloma is a cancer of the blood, characterized by accumulation of a plasma cell clone in the bone marrow. Lenalidomide is one of the novel drug agents used to treat multiple myeloma. It is a small molecular analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting tumor necrosis factor-alpha, and has less severe adverse drug reactions. In a phase III clinical study, Weber et al. found that lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma was superior to the old treatment of multiple myeloma consisting of high-dose dexamethasone alone.
Dosage of Lenalid
Always follow the instructions of doctor regarding the dosage and duration.
• Multiple Myeloma and mantle cell lymphoma: 25 mg/day on days 1 through 21 of repeated 28 day cycles.
• Myelodysplastic Diseases: 10 mg once daily.
• This information is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
Common side effects
Anemia, low levels of calcium, phosphate, potassium or magnesium in the blood, iron overload, changes to blood thyroid hormone, vasculitis (changes to a protein in the blood that can cause swelling of the arteries), muscle cramps, muscle aches and weakness, bone/ joint pain, pains in hands or feet, tiredness, generalized swelling, numbness, tingling or burning sensation, fever and flu, constipation, stomach pain, diarrhea, nausea, vomiting, decreased appetite, bleeding from the gums, stomach, or bowels, kidney problems, dehydration, sore inflamed mouth, dry mouth, difficulty swallowing, heartburn, abnormal liver test results, chest pain or shortness of breath, high or low blood pressure, irregular heartbeat, heart problems, increased sweating, depression, dizziness, fainting, confusion, mood change, difficulty sleeping, tremor, impaired balance, movement difficulty, dry skin, darkening of skin, skin eruptions, skin cracking, flaking or peeling skin, hives, itching redness of skin, rashes, blurred vision, cataract, tinnitus (ringing in the ears), deafness, toothache, weight loss, diabetes.
Who should not take
• Patients who are allergic to lenalidomide or any of its ingredients.
• Children or adolescents under 18 years of age.
• Pregnant or breastfeeding women.
Lenalid, Lenalidomide Capsules 10 mg
Lenalidomide is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic treatment. Lenalidomide has also shown efficacy in the class of hematological disorders known as myelodysplastic syndromes (MDS). Lenalidomide has significantly improved overall survival in myeloma (which generally carries a poor prognosis), although toxicity remains an issue for users.
What is Lenalid?
Lenalid is Generic version of Revlimid manufactured by Natco which is manufactured by Natco Pharma Ltd. (INDIA)
Lenalid is used for treatment of a certain type of myelodysplastic syndrome (a group of conditions in which the bone marrow produces blood cells that are misshapen and does not produce enough healthy blood cells) caused by an abnormal chromosome. Lenalid is also used for treatment of anemia (a lack of red blood cells in the body) and along with dexamethasone for the treatment of multiple myeloma (a type of cancer of the bone marrow) who have received at least one prior therapy.
What are the Indications of Lenalid?
- • Multiple Myeloma: Lenalidomide in combination with dexamethasone is indicated for the treatment of patients with multiple myeloma (MM) who have received at least one prior therapy.
- • Myelodysplastic Syndromes: Lenalidomide is indicated for the treatment of patients with transfusion-dependent anemia due to low-or intermediate-1-risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.
- • Mantle Cell Lymphoma: Lenalidomide is indicated for the treatment of patients with mantle cell lymphoma (MCL) whose disease has relapsed or progressed after two prior therapies, one of which included bortezomib.
What is the best price of Lenalid ?
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Where can I buy Lenalid ?
- • ADG connects buyer with the supplier who can ship Lanalid (Cancer Treatment Medicines) to any country of the world as per the buyer’s requirement and as per the Government regulations of the country. Lanalid is manufactured by NATCO
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Is Lanalid available in India?
Lanalid is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.
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Lanalid can be made available Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore and Pune and other cities in India”
ADG can facilitate the supply of Lanalid (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable)
How order will be confirmed ?
The order will be confirmed only after the receipt of
- • Valid prescription of Clinician
- • Import permit if applicable
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Cost of Lenalidomide Capsules Lenalid 10 in Australia, Brazil, China, Canada, Eqypt, Europe, France, Germany, Hongkong, India, Iran, Italy, Mexico, Pakistan, Poland, Spain, Singapore, Thailand, Russia, Romania, UK, Middle East, UAE, Ukraine.
Before taking Lenalid (Lenalidomide) you must tell your physician if you are receiving dialysis, have a tumor, cancer, or kidney problems.
It is extremely important that women do not become pregnant while taking this drug as it can cause birth defects in unborn children. It can also be passed on through s**ual intercourse with a man who is taking the medication. Make sure to always use precautions when having s**ual intercourse with pregnant women when taking this drug.
Expert advice for Lenalid
- • You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection and blood clotting.
• Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections.
• You should not donate blood, semen or serum during treatment and for 4 week after the end of treatment.
• You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma tumor lysis syndrome, fatal liver problems, severe skin reactions and fatal heart problems during treatment with lenalidomide. You should discuss in advance the benefits and risks of taking lenalidomide.
• Lenalidomide is not recommended for use in children and adolescents under 18 years.
• You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment.
• Woman of childbearing potential will be required to undergo pregnancy tests before, every 4 weeks and after the treatment.
• You should inform your doctor or dentist that you take lenalidomide before you receive any medical or dental care, emergency care, or surgery.
• Do not drive or operate machines while taking lenalidomide as it may make you feel dizzy, tired, sleepy or have blurred vision.
Frequently asked questions for Lenalid
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