When you were younger, as you began to exercise you’d acquire speed and distance and your legs would carry you to your destination, just or challenge. Your respiratory would quicken, your rate increase, and also the lungs and heart would work along in order that enlarged blood would flow into to the arteries and muscles of your legs. You would walk or run effortlessly.
In some individuals, however, coronary artery disease, or hardening of the arteries, restricts this blood flow. When your muscles don’t get the oxygen and nutrients they need during exercise such as walking, you may experience a cramping discomfort, squeezing or tightness in the calf called claudication . It is typically calledintermittent gimpiness as a result of the pain stops with rest, so you’ll resume walking.
This leg muscle fatigue, discomfort or pain is that the primary symptom of peripheral blood vessel illness (PAD). It most ordinarily affects the blood offer to the legs and results from clogged arteries. People with PAD could have the same disease of the arteries elsewhere in the body, such as the brain, heart or kidneys.
Many people do not expertise any leg muscle discomfort or claudication till the artery is blocked or occluded by sixty % or additional. Thus, throughout the years or perhaps decades PAD is developing, you’ll be unaware of what is happening within the arteries of your body. Even after you begin to expertise some symptoms, many folks simply assume these aches and pains within the leg muscles area unit a natural a part of obtaining previous.
However, once arteries area unit broken by coronary artery disease in one website (such because the leg arteries), they are seemingly conjointly broken in different important locations (such because the heart or brain). If a blood clot forms in a damaged artery to the heart or brain, it can lead to aheart attack or stroke.
In fact, the risk of dying from a heart attack or stroke is significantly higher in those with PAD compared to those without.
While atherosclerosis is by far the most common cause of PAD, other conditions can cause narrowing such as blood clots, injury to your limbs, inflammation of your arteries (due to other illnesses), or uncommon inheritable variations of the anatomy of your leg’s ligaments or muscles.
One in 20 people over 50 have PAD. Many people with PAD have gentle or no symptoms, and solely concerning ten % of individuals with PAD have typical claudication. Nevertheless, PAD is very common and affects about 8 million Americans.
Only a small percentage of people with PAD will ever face a risk of amputation. PAD is, however, the leading reason for amputation in individuals age fifty associate degreed over and accounts for an calculable ninety % of amputations overall.
If you’re thinking that you would possibly have PAD, talk to your doctor about your symptoms. A number of easy, risk-free and inexpensive tests can help to confirm the diagnosis.
Your risk for PAD increases if you:
- Are over age 50.
- Smoke. Tobacco use is the single greatest cause of PAD. In fact, smokers are diagnosed with PAD as much as 10 years earlier on average than nonsmokers. People with PAD who smoke are also more likely to experience worse symptoms, to require leg bypass surgery and to undergo amputation or die from PAD-related complications.
- Have diabetes. One in three people over 50 with diabetes has PAD, and those with diabetes face an increased risk of amputation due to the development of PAD.
- Have high blood pressure.
- Have high cholesterol levels.
- Have coronary artery disease.
- Have a family history of coronary artery disease or PAD.
- Have high levels of homocysteine, an amino acid, in your blood.
- Are African American
The first sign of PAD may be symptoms such as intermittent claudication: leg muscle discomfort that gets worse with exercise but improves with rest or warmth.
As PAD becomes more severe, other symptoms in the legs may occur:
- Pain in the foot at rest, or when lying down, that is not caused by arthritis or neuropathy
- Leg sores that don’t heal
- Gangrene, or tissue death
If any tissue within the body doesn’t receive the gas and nutrients required via the current blood, over time that tissue can die. With very severe PAD, the skin of the feet may break down, forming sores and ulcers and sometimes infection can occur and spread to the bone.
To diagnose PAD, your health care professional should take a thorough medical history and ask about any risk factors such as smoking, diabetes, high blood pressure or high blood cholesterol.
Your doctor also will perform a physical examination feeling the heartbeat of the arteries in key locations, such as at the groins, at the backs of your knees, the tops of your feet and just behind the bone on the inside of each ankle. Using a vital sign cuff and a special ultrasound medical instrument known as a Doppler, your doctor might also take your blood pressure on each arm and ankle.
Comparing vital sign readings between the arms and legs determines however well blood is flowing to every limb. This painless procedure is called the ankle-brachial index (or ABI ) and helps determine if further testing is needed. The ankle pressure is normally at least 90 percent of the arm pressure, but with PAD, the ankle pressure may be less than 50 percent of the arm pressure.
However, this check might not be precise enough in individuals with polygenic disease. In those cases, the doctor may take pressure measurements of your toes, or you may be referred to a vascular laboratory for more sophisticated tests described below.
Other possible tests include:
- Duplex ultrasound. This test uses sound waves to determine the site and severity of artery blockages.
- A computed tomographic angiogram (CT). This is a noninvasive test that provides an image of the arteries in the abdomen, pelvis and legs.
- Magnetic resonance angiogram (MRA). This is a noninvasive test that provides information similar to a CT scan but without the use of X-rays. The MRA provides a very detailed picture of the arteries. This test is not accurate or safe in people who have pacemakers or stents.
- Contrast arteriogram. In this test, an X-ray is taken of your arteries after a small tube (catheter) is inserted into an artery and a contrast dye injected. The dye makes areas of atherosclerosis and structural changes more obvious.
You also may want to find a local PAD screening program, such as a “Legs for Life” site. “Legs for Life” is sponsored by the Society of Interventional Radiology and has long offered free screenings for PAD. Similar screening programs are offered by the for-profit Lifeline Screening Company, other private, for-profit screening businesses, and many hospital systems throughout the country. American Vascular Association (sponsored by the Society for Vascular Surgery) also helps people find screening programs, some of which are free. If a screening test is positive, you will need to see your doctor to review these results, likely repeat the test and discuss care plans. The Peripheral blood vessel illness (PAD) Coalition conjointly offers screening choices.
Treatment goals for peripheral blood vessel malady (PAD) invariably embody reducing your risk of coronary failure and stroke by right away dominant your risk factors and thru the utilization of medicines. Additional goals square measure to boost your leg symptoms, if these square measure gift, and to scale back the chance of amputation. Once again, it is extremely important that any risk factors be recognized and treated promptly so that your PAD doesn’t get worse.
Lifestyle can profoundly affect your health. If you expose your arteries to damaging factors, you should note that other treatments may not be effective and your health is likely to deteriorate. On the opposite hand, successful control of your daily habits can usually be enough to slow the progression or even reverse symptoms of PAD. These beneficial lifestyle changes include:
- Stop smoking immediately. This is critical because all tobacco products directly damage the arteries, and nicotine further narrows the blood vessels.
- Exercise. Regular exercise is that the most systematically effective treatment for folks with PAD. When you walk, your body develops new blood vessels. Walking helps to scale back steroid alcohol levels, improve weight loss and maintain healthy circulation. Exercise programs square measure simplest once performed in a very supervised setting like a viscus program. Simple walking regimens on a treadmill, outdoors or in malls for at least 30 to 60 minutes, five or more times a week, may also help. Your health care professional is likely to ask you to walk each day until leg discomfort develops, then rest, then continue walking until the pain develops again. The goal is to travel longer distances while not pain on every occasion you walk.
- Watch your diet. Many people with PAD have high steroid alcohol and pressure levels. A healthful, diet low in saturated fat, salt and steroid alcohol, and rich in fruits, vegetables, whole grains, beans, fish and low-fat dairy products may help lower cholesterol levels and high blood pressure. However, some folks might need medication to scale back steroid alcohol and/or pressure levels and keep them low.
- Maintain good foot hygiene. Check your feet day by day for sores, redness or swelling. Wash your feet every day and apply a moisturizing lotion; tuck cotton or lamb’s wool between your toes if the skin is starting to crack; and wear cotton socks and comfortable, breathable shoes made of natural materials. Avoid injuring your feet.
Treatment for PAD always includes the use of medication to reduce the risk of heart attack and stroke and improve symptoms. Medications used include:
- Antiplatelet medications. These medicine, like pain pill or clopidogrel (Plavix), help reduce your risk of heart attack and stroke. Side effects of aspirin include stomach ulcers and bleeding complications. Side effects of clopidogrel embody hypersensitivity, bleeding complications, severe headache, confusion or dizziness. Other, less serious facet effects might embody indigestion, looseness of the bowels or constipation, or headache or dizziness.
- Cholesterol-lowering drugs such as statins. Thesemedicine not solely lower steroid alcohol however conjointly improve the health of the liner of the arteries ( epithelium ) associated cut back the chance that an artery can slowly clog or suddenly be blocked by a blood.Most individuals tolerate statins with no issue. However, attainable facet effects embody nausea, gas, constipation and muscle pain. Your physician will also monitor your liver function. Any facet effects square measure sometimes delicate and fade as your body adjusts to the drug. If you expertise any uncommon or persistent muscle soreness or weakness whereas exploitation these medications, contact your health care skilled right away.
- Cilostazol (Pletal). This drug widens the arteries that supply blood to the legs. It is particularly effective when combined with exercise. Side effects are rare and include headache, mild palpitations, loose stools and nausea. You should not take this medication if you have congestive heart failure.
There are a number of ways health care professionals can open blood vessels at the site of blockages and restore normal blood flow. All of those invasive PAD treatments, whether based on use of a catheter or surgery, are most useful for individuals whose blockages are not widespread or whose blockages are in the arteries closer to the groin.
In these instances, a nonsurgical endovascular procedure can sometimes bring swift relief and may be more cost-effective than surgery. Most endovascular procedures need no quite associate long hospital keep and small down time later.
In these procedures, a tiny tube called a catheter is inserted into an artery to open the blockage. The most common procedures treat the plaque by compressing it and/or displacing it with a metal coil inserted within the artery, called a stent. The two main procedures are:
- Angioplasty. With the help of a catheter and X-ray guidance, a tiny balloon is inserted into the blood vessel through a small opening in the skin and moved through the artery to the site of the blockage, then inflated to open the blood vessel.
- Stenting. A tiny metal cylinder or “stent” is permanently inserted in the clogged vessel, where it acts like a scaffold to hold it open.
More rarely, physicians may identify a clot that is blocking an artery, stent or bypass graft. If so, thrombolytic therapy may be used:
- Thrombolytic therapy. If you have a clot that’s blocking an artery, your doctor may inject a clot-dissolving drug into your artery where the clot is located to break it up.
- Endarterectomy. This procedure is used when a very short segment of an artery is blocked or severely clogged. The physician identifies the situation of the blockage, then makes an incision over the area and removes the plaque in the artery’s inner lining. This procedure opens the artery, restoring blood flow. It is used most ordinarily for clogged artery arteries within the neck and fewer typically for blockages of the leg arteries.
- Bypass. If the blockage is extremely long or has become very hard and calcified with time, surgery may be required to bypass the problem area. A bypass involves using one of the patients own veins from another part of the body or a synthetic graft to bypass the diseased region of the artery.
- Amputation. In rare cases, gangrenous tissue (such as a toe, foot or leg) may have to be removed permanently.
There are several things you can do to prevent PAD, including:
- Quit smoking. Smoking damages the inner lining of vessels and makes blood clot more easily.
- Exercise regularly under the supervision of your health care provider to prevent the buildup of cholesterol, help with weight loss and maintain healthy circulation.
- Eat a low-fat, low-salt, balanced diet that includes vegetables, fruits, whole grains, beans and low-fat dairy, poultry, fish and meats. People with PAD often have elevated cholesterol levels and high blood pressure, both of which can be controlled with a healthy diet.
- Reach and maintain a healthy weight.
- Keep good control of your blood glucose levels, if you have diabetes.
Your Best Source of PAD Health Information
The national, nonprofit Peripheral Arterial Disease Coalition is a good source for unbiased, up-to-date information on PAD. The PAD Coalition combines health information from numerous major national vascular professional societies, health organizations and government agencies.
Facts to Know
- Peripheral arterial disease (PAD) is primarily caused by atherosclerosis, or hardening of the arteries.
- Up to 20 percent of people over 70 may suffer from PAD. Unfortunately, many of them consider PAD’s leg pain as simply part of getting older and don’t get treatment.
- PAD is associated with a high short-term risk of heart attack and stroke and a very low risk of development of non-healing wounds, gangrene and amputation.
- For most individuals with claudication, a program of supervised exercise may be all that is required to improve the symptoms of PAD. Regular exercise is the most consistently effective treatment of PAD because it reconditions weakened muscles, helps decrease buildup of cholesterol, improves blood pressure, improves diabetes control, assists in weight-loss efforts and helps maintain healthy circulation.
- Smoking is the single most important risk factor for PAD because many components of tobacco directly damage the artery.
- Unfortunately, only about 20 percent to 30 percent of people with PAD undergo treatment for the condition.
- People with PAD often have elevated cholesterol levels and high blood pressure, which can be brought under control through diet and medications.
- There are several medications that can help you achieve your PAD treatment goals. The risk of heart attack and stroke can be reduced with aspirin and medications that reduce blood pressure and cholesterol levels and improve diabetic control. Other medications can improve the symptoms of claudication by helping blood reach the leg muscles despite arterial blockages.
- If exercise and medications aren’t effective in improving claudication, the symptoms can sometimes be treated with nonsurgical procedures that involve only a small nick in the skin and the use of small balloon-tipped catheters (tubes) under X-ray guidance to open arteries. Specialized physicians perform these procedures, which usually require only an overnight stay in the hospital and little recuperation time.
- Surgery, in which closed arteries are bypassed, is rarely required but may be an option if there is a risk of amputation, or if all other exercise, medication and angioplasty options are ineffective or are not feasible.
- If I have leg pain, does that mean I have peripheral arterial disease (PAD)?No. There are many other causes of leg pain, such as orthopedic diseases (such as joint disease or arthritis) or diseases of the nervous system (neuropathy). In any case, you should discuss any leg pain with your health care professional.
- I don’t have leg pain; could I still have PAD?Yes, you could, for many reasons. For example, claudication doesn’t usually develop until the arteries are blocked by 60 percent or more. Or, despite the presence of very severe blockages, you may not walk enough to notice the typical symptoms.
- I have been diagnosed with PAD. Am I going to need surgery?Most likely you will not. The choice of this or any PAD treatment will depend on the severity of your condition and many other factors, but the majority of individuals with PAD are treated without surgery.
- If walking hurts my legs, why is my health care professional suggesting I walk?Exercise is the most consistently effective treatment for intermittent claudication, as is proven by a number of studies. Exercise helps strengthen the leg muscles that are usually weakened by the lack of walking that you have done. And, for any amount of blood flow you have to the leg muscles, strengthening these muscles helps you walk farther with less pain. Exercise, unlike angioplasty or surgery, is known to decrease the buildup of cholesterol, improve blood pressure and diabetes control, assist in weight-loss efforts and help maintain healthy circulation. Your health care professional has probably suggested that you walk until your legs start to hurt and then stop to rest, alternating walking and resting for a certain number of minutes each day. Eventually you should find that you can walk greater and greater distances without pain. If you do not walk, your leg muscles will surely weaken, and no treatment can strengthen muscles that are allowed to atrophy. Exercise is essential.
- What can I do if lifestyle changes don’t do enough?There are a number of medications and medical procedures that can be used to treat PAD.
- How does smoking cause PAD and pain in my leg muscles?Numerous components of tobacco narrow blood vessels, making it more difficult for blood to flow through them and damaging artery linings, causing scar tissue to form in the affected areas, which further narrows the artery. Tobacco constricts all vessels and promotes formation of blood clots. All this leads to worsened leg artery blood flow, so the muscles in your legs don’t get the oxygen- and nutrient-rich blood they need. That, in turn, causes the pain and cramping of intermittent claudication.
- How does diabetes contribute to PAD?People with diabetes have a high risk for developing PAD because of the damaging effects of uncontrolled blood sugar on arteries. Diabetes also worsens blood pressure and blood cholesterol levels. Untreated, the disease may also lead to amputation. Caution and care should be given to preventing and detecting foot sores that can quickly become seriously infected, leading to gangrene (tissue death).
- I’m still relatively young. Do I need to worry about PAD?Yes. Any adult can develop PAD. Although the risk increases with age, it also increases with exposure to any of the risk factors, such as smoking, diabetes, high blood pressure or high blood cholesterol. Younger people are affected with PAD when they have these risk factors. Overall, approximately 8 million to 12 million Americans are affected.